CHA4/YLR098C Summary Help

Standard Name CHA4 1
Systematic Name YLR098C
Alias SIL2 2 , SIL3 2
Feature Type ORF, Verified
Description DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain (1, 3)
Name Description Catabolism of Hydroxy Amino acids 1, 4
Chromosomal Location
ChrXII:339473 to 337527 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CHA4 GO evidence and references
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 88 genes
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
79 total interaction(s) for 75 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 5
  • Two-hybrid: 16

Genetic Interactions
  • Negative Genetic: 41
  • Phenotypic Enhancement: 2
  • Positive Genetic: 10
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 648
Molecular Weight (Da) 74,392
Isoelectric Point (pI) 6.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:339473 to 337527 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1947 339473..337527 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004088
References cited on this page View Complete Literature Guide for CHA4
1) Holmberg S and Schjerling P  (1996) Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements. Genetics 144(2):467-78
2) Pedersen JO, et al.  (1997) Locus-specific suppression of ilv1 in Saccharomyces cerevisiae by deregulation of CHA1 transcription. Mol Gen Genet 255(6):561-9
3) Schjerling P and Holmberg S  (1996) Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators. Nucleic Acids Res 24(23):4599-607
4) Petersen JG, et al.  (1988) Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. Genetics 119(3):527-34
5) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87