GAA1/YLR088W Summary Help

Standard Name GAA1 1
Systematic Name YLR088W
Alias END2 2
Feature Type ORF, Verified
Description Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER (3)
Name Description GPI Anchor Attachment 1
Chromosomal Location
ChrXII:316107 to 317951 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GAA1 GO evidence and references
  View Computational GO annotations for GAA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
27 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Co-purification: 1
  • PCA: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 614
Molecular Weight (Da) 69,220
Isoelectric Point (pI) 6.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:316107 to 317951 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1845 316107..317951 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004078
References cited on this page View Complete Literature Guide for GAA1
1) Hamburger D, et al.  (1995) Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins. J Cell Biol 129(3):629-39
2) Chvatchko Y, et al.  (1986) Two yeast mutants defective in endocytosis are defective in pheromone response. Cell 46(3):355-64
3) Fraering P, et al.  (2001) The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol Biol Cell 12(10):3295-306