Standard Name	GAA1 1
Systematic Name	YLR088W
Alias	END2 2
Feature Type	ORF, Verified
Description	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER (3)
Name Description	GPI Anchor Attachment 1

Chromosomal Location	ChrXII:316107 to 317951 | ORF Map | GBrowse

	View Computational GO annotations for GAA1
Molecular Function
Manually curated	GPI-anchor transamidase activity (IMP, IPI)
Biological Process
Manually curated	attachment of GPI anchor to protein (IMP)
Cellular Component
Manually curated	GPI-anchor transamidase complex (IPI)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	heat sensitivity: increased
null	inviable
reduction of function	pheromone-induced cell cycle arrest: decreased shmoo formation: decreased
unspecified	GPI-anchored protein modification: decreased
Large-scale survey
null	inviable starvation resistance: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to tunicamycin: decreased
repressible	cytokinesis: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	25 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 PCA: 5 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 5 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 1 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:316107 to 317951 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1845 316107..317951 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004078