SED5/YLR026C Summary Help

SED5 BASIC INFORMATION

Standard Name SED5
Systematic Name YLR026C
Feature Type ORF, Verified
Description cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins (1, 2, 3, 4, 5)
Name Description Suppressor of Erd2 Deletion 6
GO Annotations All SED5 GO evidence and references
    View Computational GO annotations for SED5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SED5 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions SED5 All interactions details and references
196 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 70
  • Co-crystal Structure: 1
  • Co-fractionation: 3
  • Co-purification: 44
  • Reconstituted Complex: 42
  • Two-hybrid: 9
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 10
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 2
Sequence Information
ChrXII:196473 to 195451 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1023 196473..195451 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004016

SED5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SED5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SED5]

1) Hardwick KG and Pelham HR  (1992) SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. J Cell Biol 119(3):513-21
2) Peng R, et al.  (1999) Specific interaction of the yeast cis-Golgi syntaxin Sed5p and the coat protein complex II component Sec24p of endoplasmic reticulum-derived transport vesicles. Proc Natl Acad Sci U S A 96(7):3751-6
3) Sacher M, et al.  (1997) The synaptobrevin-related domains of Bos1p and Sec22p bind to the syntaxin-like region of Sed5p. J Biol Chem 272(27):17134-8
4) Grabowski R and Gallwitz D  (1997) High-affinity binding of the yeast cis-Golgi t-SNARE, Sed5p, to wild-type and mutant Sly1p, a modulator of transport vesicle docking. FEBS Lett 411(2-3):169-72
5) Tsui MM, et al.  (2001) Selective formation of Sed5p-containing SNARE complexes is mediated by combinatorial binding interactions. Mol Biol Cell 12(3):521-38
6) Hardwick KG, et al.  (1992) Genes that allow yeast cells to grow in the absence of the HDEL receptor. EMBO J 11(11):4187-95