POM34/YLR018C Summary Help

Standard Name POM34 1
Systematic Name YLR018C
Feature Type ORF, Verified
Description Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication (1, 2, 3, 4, 5)
Name Description POre Membrane 1
Chromosomal Location
ChrXII:179606 to 178707 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All POM34 GO evidence and references
  View Computational GO annotations for POM34
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
unspecified
Resources
160 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 21
  • Protein-RNA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 65
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 11
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 299
Molecular Weight (Da) 34,232
Isoelectric Point (pI) 10.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:179606 to 178707 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..900 179606..178707 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004008
References cited on this page View Complete Literature Guide for POM34
1) Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
2) Miao M, et al.  (2006) The integral membrane protein pom34p functionally links nucleoporin subcomplexes. Genetics 172(3):1441-57
3) Onischenko E, et al.  (2009) Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J Cell Biol 185(3):475-91
4) Sezen B, et al.  (2009) The SESA network links duplication of the yeast centrosome with the protein translation machinery. Genes Dev 23(13):1559-70
5) Witkin KL, et al.  (2010) Changes in the Nuclear Envelope Environment Affect Spindle Pole Body Duplication in Saccharomyces cerevisiae. Genetics 186(3):867-83