TEN1/YLR010C Summary Help

Standard Name TEN1 1
Systematic Name YLR010C
Feature Type ORF, Verified
Description Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex (1, 2)
Name Description TElomeric pathways with STn1 1
Chromosomal Location
ChrXII:167802 to 167320 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TEN1 GO evidence and references
  View Computational GO annotations for TEN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
null
overexpression
reduction of function
repressible
Large-scale survey
null
reduction of function
unspecified
Resources
34 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 6
  • Co-fractionation: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 160
Molecular Weight (Da) 18,604
Isoelectric Point (pI) 7.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:167802 to 167320 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..483 167802..167320 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004000
References cited on this page View Complete Literature Guide for TEN1
1) Grandin N, et al.  (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J 20(5):1173-83
2) Bryan C, et al.  (2013) Structure of the human telomeric stn1-ten1 capping complex. PLoS One 8(6):e66756