NOC3/YLR002C Summary

NOC3 BASIC INFORMATION

Standard Name	NOC3
Systematic Name	YLR002C
Feature Type	ORF, Verified
Description	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation (1, 2)
Name Description	NucleOlar Complex

GO Annotations	All NOC3 GO evidence and references
	View Computational GO annotations for NOC3
Molecular Function
Manually curated	chromatin binding (IDA) protein binding (IDA)
Biological Process
Manually curated	DNA replication initiation (IDA) rRNA processing (IDA)
Cellular Component
Manually curated	Noc2p-Noc3p complex (IPI) nucleolus (TAS) nucleus (IDA)

Mutant Phenotype	All NOC3 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	NOC3 All interactions details and references
	98 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 76 Affinity Capture-Western: 12 Co-fractionation: 1
Genetic Interactions	Dosage Rescue: 5 Synthetic Lethality: 4

Sequence Information

ChrXII:156333 to 154342 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1992	156333..154342	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003992

NOC3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NOC3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NOC3]

1)	Milkereit P, et al. (2001) Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105(4):499-509
2)	Zhang Y, et al. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109(7):849-60

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