LDB18/YLL049W Summary Help

Standard Name LDB18 1
Systematic Name YLL049W
Feature Type ORF, Verified
Description Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 (1, 2, 3)
Name Description Low Dye Binding 1
Chromosomal Location
ChrXII:40666 to 41205 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LDB18 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
246 total interaction(s) for 142 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 10
  • Co-fractionation: 3
  • Two-hybrid: 15

Genetic Interactions
  • Negative Genetic: 162
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 25
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 179
Molecular Weight (Da) 20,847
Isoelectric Point (pI) 4.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:40666 to 41205 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..540 40666..41205 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003972
References cited on this page View Complete Literature Guide for LDB18
1) Corbacho I, et al.  (2005) A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Fungal Genet Biol 42(9):773-90
2) Ye P, et al.  (2005) Gene function prediction from congruent synthetic lethal interactions in yeast. Mol Syst Biol 1():2005.0026
3) Amaro IA, et al.  (2008) The Saccharomyces cerevisiae Homolog of p24 Is Essential for Maintaining the Association of p150Glued With the Dynactin Complex. Genetics 178(2):703-9