FPS1/YLL043W Summary Help

Standard Name FPS1 1
Systematic Name YLL043W
Feature Type ORF, Verified
Description Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; role in mediating passive diffusion of glycerol is key factor in maintenance of redox balance; member of major intrinsic protein (MIP) family; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation (2, 3, 4, 5, 6, 7)
Name Description fdp1 Suppressor 1
Chromosomal Location
ChrXII:49938 to 51947 | ORF Map | GBrowse
Gene Ontology Annotations All FPS1 GO evidence and references
  View Computational GO annotations for FPS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
gain of function
Large-scale survey
262 total interaction(s) for 177 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 9
  • PCA: 10
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 10
  • Negative Genetic: 176
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 8
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 10
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 669
Molecular Weight (Da) 73,877
Isoelectric Point (pI) 6.9
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXII:49938 to 51947 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2010 49938..51947 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003966
References cited on this page View Complete Literature Guide for FPS1
1) Van Aelst L, et al.  (1991) A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling. EMBO J 10(8):2095-104
2) Tamas MJ, et al.  (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104
3) Luyten K, et al.  (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71
4) Wysocki R, et al.  (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401
5) Mollapour M and Piper PW  (2007) Hog1 mitogen-activated protein kinase phosphorylation targets the yeast fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic Acid. Mol Cell Biol 27(18):6446-56
6) Wei N, et al.  (2013) Deletion of FPS1, Encoding Aquaglyceroporin Fps1p, Improves Xylose Fermentation by Engineered Saccharomyces cerevisiae. Appl Environ Microbiol 79(10):3193-201
7) Lourenco AB, et al.  (2013) Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin FPS1 in ethanol-stressed yeast cells. PLoS One 8(2):e55439