EMC6/YLL014W Summary Help

Standard Name EMC6 1
Systematic Name YLL014W
Feature Type ORF, Verified
Description Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 (1, 2)
Name Description ER Membrane protein Complex 1
Chromosomal Location
ChrXII:121322 to 121648 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EMC6 GO evidence and references
  View Computational GO annotations for EMC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
unspecified
Resources
98 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 69
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 2
  • Positive Genetic: 10
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 108
Molecular Weight (Da) 12,404
Isoelectric Point (pI) 4.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:121322 to 121648 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..327 121322..121648 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003937
References cited on this page View Complete Literature Guide for EMC6
1) Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
2) Richard M, et al.  (2013) Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Proc Natl Acad Sci U S A 110(11):E1055-63