DRS1/YLL008W Summary Help

Standard Name DRS1 1
Systematic Name YLL008W
Feature Type ORF, Verified
Description Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles (2, 3, 4)
Name Description Deficiency of Ribosomal Subunits 1
Chromosomal Location
ChrXII:131729 to 133987 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DRS1 GO evidence and references
  View Computational GO annotations for DRS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
dominant negative
null
Large-scale survey
null
reduction of function
Resources
128 total interaction(s) for 95 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 91
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 18
  • Reconstituted Complex: 8
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 752
Molecular Weight (Da) 84,842
Isoelectric Point (pI) 5.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:131729 to 133987 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2259 131729..133987 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003931
References cited on this page View Complete Literature Guide for DRS1
1) Ripmaster TL, et al.  (1992) A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Proc Natl Acad Sci U S A 89(23):11131-5
2) Ripmaster TL, et al.  (1993) DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7901-12
3) Adams CC, et al.  (2002) Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. RNA 8(2):150-65
4) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27