MGM101/YJR144W Summary Help

Standard Name MGM101 1
Systematic Name YJR144W
Alias MGM9
Feature Type ORF, Verified
Description Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage (1, 2, 3, 4, 5)
Name Description Mitochondrial Genome Maintenance 1
Chromosomal Location
ChrX:700882 to 701691 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MGM101 GO evidence and references
  View Computational GO annotations for MGM101
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
overexpression
Resources
214 total interaction(s) for 178 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 101
  • Phenotypic Enhancement: 1
  • Positive Genetic: 56
  • Synthetic Growth Defect: 15

Resources
Expression Summary
histogram
Resources
Length (a.a.) 269
Molecular Weight (Da) 30,090
Isoelectric Point (pI) 10.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:700882 to 701691 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..810 700882..701691 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003905
References cited on this page View Complete Literature Guide for MGM101
1) Chen XJ, et al.  (1993) MGM101, a nuclear gene involved in maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Nucleic Acids Res 21(15):3473-7
2) Meeusen S, et al.  (1999) Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA. J Cell Biol 145(2):291-304
3) Zuo X, et al.  (2007) A functional core of the mitochondrial genome maintenance protein Mgm101p in Saccharomyces cerevisiae determined with a temperature-conditional allele. FEMS Yeast Res 7(1):131-40
4) Mbantenkhu M, et al.  (2011) Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination. J Biol Chem 286(49):42360-70
5) Ward TA, et al.  (2012) Components of a fanconi-like pathway control pso2-independent DNA interstrand crosslink repair in yeast. PLoS Genet 8(8):e1002884