Standard Name	HIR3
Systematic Name	YJR140C
Alias	HPC1
Feature Type	ORF, Verified
Description	Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein (1, 2, 3, 4, 5, 6, 7)
Name Description	HIstone Regulation 2

Chromosomal Location	ChrX:695696 to 690750 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HIR3
Molecular Function
Manually curated	contributes_to DNA binding (IDA) contributes_to nucleosome binding (IMP) transcription corepressor activity (IMP)
Biological Process
Manually curated	DNA replication-independent nucleosome assembly (IDA) regulation of transcription involved in G1/S phase of mitotic cell cycle (IMP) transcription elongation from RNA polymerase II promoter (IGI)
Cellular Component
Manually curated	HIR complex (IDA, IPI) nucleus (IDA)

Regulatory modules	predicted: stressResponse (457)
Resources	YeTFaSCo

Classical genetics
null	chronological lifespan: increased replicative lifespan: increased
unspecified	histone mRNA accumulation: abnormal
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased Hta1p-GFP accumulation: increased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to cycloheximide: increased resistance to benomyl: decreased resistance to bleomycin: decreased resistance to fluconazole: decreased transposable element transposition: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	254 total interaction(s) for 154 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 3 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 187 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 14 Synthetic Growth Defect: 15 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:695696 to 690750 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YJR140W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4947 695696..690750 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003901