Standard Name	MET5 1
Systematic Name	YJR137C
Alias	ECM17 2
Feature Type	ORF, Verified
Description	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine (3, 4)
Name Description	METhionine requiring 1

Chromosomal Location	ChrX:683285 to 678957 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 84 cM

	View Computational GO annotations for MET5
Molecular Function
Manually curated	contributes_to sulfite reductase (NADPH) activity (IDA)
Biological Process
Manually curated	sulfate assimilation (IMP) sulfur amino acid biosynthetic process (IMP)
Cellular Component
Manually curated	sulfite reductase complex (NADPH) (IDA)
High-throughput	cytoplasm (IDA)

Pathways	sulfate assimilation pathway superpathway of sulfur amino acid biosynthesis

Classical genetics
null	auxotrophy tellurium atom accumulation: decreased resistance to tellurite: increased resistance to Calcofluor White: decreased
reduction of function	auxotrophy hydrogen sulfide excretion: decreased
unspecified	resistance to hygromycin B: decreased resistance to enzymatic treatment: decreased transposable element transposition: decreased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased filamentous growth: decreased haploinsufficient resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to cycloheximide: decreased resistance to elesclomol-Cu: decreased resistance to amitrole: decreased utilization of nitrogen source: absent viable
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Biochemical Activity: 1
Genetic Interactions	Negative Genetic: 25 Positive Genetic: 10 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:683285 to 678957 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 84 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4329 683285..678957 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003898