TTI2/YJR136C Summary Help

Standard Name TTI2 1
Systematic Name YJR136C
Feature Type ORF, Verified
Description Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm (1, 2, 3, 4)
Name Description Two Tel2-Interacting protein 1
Chromosomal Location
ChrX:678706 to 677441 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TTI2 GO evidence and references
  View Computational GO annotations for TTI2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
null
Resources
208 total interaction(s) for 204 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 144
  • Phenotypic Suppression: 1
  • Positive Genetic: 57
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 421
Molecular Weight (Da) 48,648
Isoelectric Point (pI) 6.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:678706 to 677441 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1266 678706..677441 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003897
References cited on this page View Complete Literature Guide for TTI2
1) Shevchenko A, et al.  (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9(11):R167
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
4) Stirling PC, et al.  (2011) The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components. PLoS Genet 7(4):e1002057