MCM22/YJR135C Summary Help

Standard Name MCM22 1
Systematic Name YJR135C
Feature Type ORF, Verified
Description Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 (1, 2, 3)
Name Description MiniChromosome Maintenance 4
Chromosomal Location
ChrX:676778 to 676059 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MCM22 GO evidence and references
  View Computational GO annotations for MCM22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
193 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 34
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Co-crystal Structure: 1
  • Two-hybrid: 13

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 72
  • Phenotypic Enhancement: 2
  • Positive Genetic: 8
  • Synthetic Growth Defect: 33
  • Synthetic Lethality: 20

Resources
Expression Summary
histogram
Resources
Length (a.a.) 239
Molecular Weight (Da) 27,567
Isoelectric Point (pI) 5.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:676778 to 676059 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..720 676778..676059 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003896
References cited on this page View Complete Literature Guide for MCM22
1) Poddar A, et al.  (1999) MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission. Mol Microbiol 31(1):349-60
2) Measday V, et al.  (2002) Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Genes Dev 16(1):101-13
3) Schleiffer A, et al.  (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13
4) Maine GT, et al.  (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106(3):365-85