JHD2/YJR119C Summary Help

JHD2 BASIC INFORMATION

Standard Name JHD2 1, 2
Systematic Name YJR119C
Alias KDM5 3
Feature Type ORF, Verified
Description JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation (1, 2, 4, 5)
Name Description JmjC domain-containing Histone Demethylase 1, 2
Gene Product Alias KDM5 6
GO Annotations All JHD2 GO evidence and references
    View Computational GO annotations for JHD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All JHD2 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
Interactions JHD2 All interactions details and references
39 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Biochemical Activity: 8
  • Co-localization: 1
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 24
  • Phenotypic Suppression: 2
Sequence Information
ChrX:646480 to 644294 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2187 646480..644294 2009-02-18 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003880

JHD2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for JHD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for JHD2]

1) Liang G, et al.  (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5
2) Tu S, et al.  (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71
3) Ingvarsdottir K, et al.  (2007) Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae. Mol Cell Biol 27(22):7856-64
4) Seward DJ, et al.  (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2
5) Mersman DP, et al.  (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62
6) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6