STE24/YJR117W Summary Help

Standard Name STE24
Systematic Name YJR117W
Alias AFC1 1 , PIO2
Feature Type ORF, Verified
Description Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans (1, 2, 3, 4)
Name Description STErile
Chromosomal Location
ChrX:642007 to 643368 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STE24 GO evidence and references
  View Computational GO annotations for STE24
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
458 total interaction(s) for 233 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 3
  • Co-purification: 1
  • PCA: 43
  • Protein-RNA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 315
  • Phenotypic Enhancement: 16
  • Phenotypic Suppression: 30
  • Positive Genetic: 16
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 453
Molecular Weight (Da) 52,324
Isoelectric Point (pI) 8.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:642007 to 643368 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1362 642007..643368 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003878
References cited on this page View Complete Literature Guide for STE24
1) Boyartchuk VL, et al.  (1997) Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275(5307):1796-800
2) Tam A, et al.  (1998) Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. J Cell Biol 142(3):635-49
3) Fujimura-Kamada K, et al.  (1997) A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor. J Cell Biol 136(2):271-85
4) Tam A, et al.  (2001) The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J Biol Chem 276(50):46798-806