NNF1/YJR112W Summary

NNF1 BASIC INFORMATION

Standard Name	NNF1
Systematic Name	YJR112W
Feature Type	ORF, Verified
Description	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation (1, 2)
Name Description	Necessary for Nuclear Function 1

GO Annotations	All NNF1 GO evidence and references
	View Computational GO annotations for NNF1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromosome segregation (IDA)
Cellular Component
Manually curated	kinetochore (IDA) nuclear MIS12/MIND type complex (IDA) spindle pole (IDA)

Mutant Phenotype	All NNF1 Phenotype details and references
Large-scale survey
null	inviable

Interactions	NNF1 All interactions details and references
	72 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-Western: 14 Biochemical Activity: 1 Co-fractionation: 3 PCA: 1 Two-hybrid: 28
Genetic Interactions	Dosage Rescue: 4 Phenotypic Suppression: 1 Synthetic Lethality: 1

Sequence Information

ChrX:637020 to 637625 | |

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..606	637020..637625	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003873

NNF1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NNF1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NNF1]

1)	Shan X, et al. (1997) NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export. J Cell Sci 110 ( Pt 14)():1615-24
2)	Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40

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