IME1/YJR094C Summary Help

Standard Name IME1 1
Systematic Name YJR094C
Feature Type ORF, Verified
Description Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA (2, 3, 4)
Name Description Inducer of MEiosis 1
Chromosomal Location
ChrX:605651 to 604569 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IME1 GO evidence and references
  View Computational GO annotations for IME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
overexpression
unspecified
Large-scale survey
null
Resources
142 total interaction(s) for 123 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 12
  • Negative Genetic: 96
  • Phenotypic Enhancement: 2
  • Positive Genetic: 9
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 360
Molecular Weight (Da) 41,858
Isoelectric Point (pI) 5.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:605651 to 604569 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1083 605651..604569 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003854
References cited on this page View Complete Literature Guide for IME1
1) Kassir Y, et al.  (1988) IME1, a positive regulator gene of meiosis in S. cerevisiae. Cell 52(6):853-62
2) Guttmann-Raviv N, et al.  (2002) Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol 22(7):2047-56
3) Kassir Y, et al.  (2003) Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol 224():111-71
4) van Werven FJ, et al.  (2012) Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell 150(6):1170-81