GRR1/YJR090C Summary Help

GRR1 BASIC INFORMATION

Standard Name GRR1
Systematic Name YJR090C
Alias CAT80 , COT2 1 , SSU2 , SDC1
Feature Type ORF, Verified
Description F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Glucose Repression-Resistant 9
GO Annotations All GRR1 GO evidence and references
    View Computational GO annotations for GRR1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All GRR1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions GRR1 All interactions details and references
115 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 27
  • Co-localization: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 12
Genetic Interactions
  • Dosage Lethality: 5
  • Dosage Rescue: 11
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 8
  • Synthetic Rescue: 11
Sequence Information
ChrX:594319 to 590864 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 60 cM
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3456 594319..590864 2009-02-18 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003850

GRR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for GRR1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SDC1Nomenclature conflictSDC1 has been used in the literature to refer to both SDC1/YDR469W and GRR1/YJR090C.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GRR1]

1) Conklin DS, et al.  (1993) The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae. Mol Cell Biol 13(4):2041-9
2) Kim YJ, et al.  (1994) Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation. J Cell Biol 127(5):1381-94
3) Erickson JR and Johnston M  (1994) Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae. Genetics 136(4):1271-8
4) Vallier LG, et al.  (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136(4):1279-85
5) Li FN and Johnston M  (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J 16(18):5629-38
6) Barral Y, et al.  (1995) G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev 9(4):399-409
7) Avram D and Bakalinsky AT  (1996) Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae. Genetics 144(2):511-21
8) Flick JS and Johnston M  (1991) GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol Cell Biol 11(10):5101-12
9) Bailey RB and Woodword A  (1984) Isolation and characterization of a pleiotropic glucose repression resistant mutant of Saccharomyces cerevisiae. Mol Gen Genet 193(3):507-12