BIR1/YJR089W Summary Help

BIR1 BASIC INFORMATION

Standard Name BIR1
Systematic Name YJR089W
Feature Type ORF, Verified
Description Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension (1, 2, 3, 4)
Name Description Baculoviral IAP Repeat-containing protein 1
GO Annotations All BIR1 GO evidence and references
    View Computational GO annotations for BIR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All BIR1 Phenotype details and references
Classical genetics
conditional
null
overexpression
Interactions BIR1 All interactions details and references
47 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 10
  • Biochemical Activity: 4
  • Co-localization: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 16
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 4
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1
Sequence Information
ChrX:587710 to 590574 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2865 587710..590574 2009-02-18 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003849

BIR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for BIR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BIR1]

1) Yoon HJ and Carbon J  (1999) Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Proc Natl Acad Sci U S A 96(23):13208-13
2) Li F, et al.  (2000) Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast. J Biol Chem 275(10):6707-11
3) Nakajima Y, et al.  (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84
4) Makrantoni V and Stark MJ  (2009) Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1. Mol Cell Biol 29(16):4552-62