Standard Name	HOC1
Systematic Name	YJR075W
Feature Type	ORF, Verified
Description	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele (1, 2, 3)
Name Description	Homologous to OCh1 1

Chromosomal Location	ChrX:573981 to 575171 | ORF Map | GBrowse

	View Computational GO annotations for HOC1
Molecular Function
Manually curated	contributes_to alpha-1,6-mannosyltransferase activity (IDA) transferase activity, transferring glycosyl groups (ISS)
Biological Process
Manually curated	cell wall mannoprotein biosynthetic process (TAS) substituted mannan metabolic process (TAS)
Cellular Component
Manually curated	alpha-1,6-mannosyltransferase complex (IDA, IPI)

Classical genetics
null	Hsp150p distribution: abnormal Ccw14p distribution: abnormal
Large-scale survey
null	anaerobic growth: decreased auxotrophy cell size: increased glycogen accumulation: increased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased hyperosmotic stress resistance: increased protein transport: abnormal resistance to cycloheximide: increased resistance to fluconazole: increased resistance to amiodarone: decreased resistance to PM02734: decreased resistance to ethanol: decreased resistance to arsenite(3-): decreased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to sulfometuron methyl: decreased resistance to Echinacea extract: decreased resistance to acetic acid: decreased resistance to bleomycin: decreased resistance to (S)-lactic acid: increased resistance to hygromycin B: decreased sporulation efficiency: increased stress resistance: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	340 total interaction(s) for 220 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 11 Biochemical Activity: 1 PCA: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 222 Positive Genetic: 17 Synthetic Growth Defect: 43 Synthetic Lethality: 23
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:573981 to 575171 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1191 573981..575171 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003836