HOC1/YJR075W Summary Help

Standard Name HOC1 1
Systematic Name YJR075W
Feature Type ORF, Verified
Description Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele (1, 2, 3)
Name Description Homologous to OCh1 1
Chromosomal Location
ChrX:573981 to 575171 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HOC1 GO evidence and references
  View Computational GO annotations for HOC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
465 total interaction(s) for 284 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 344
  • Positive Genetic: 16
  • Synthetic Growth Defect: 45
  • Synthetic Lethality: 23

Resources
Expression Summary
histogram
Resources
Length (a.a.) 396
Molecular Weight (Da) 46,297
Isoelectric Point (pI) 8.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:573981 to 575171 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1191 573981..575171 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003836
References cited on this page View Complete Literature Guide for HOC1
1) Neiman AM, et al.  (1997) Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase. Genetics 145(3):637-45
2) Hashimoto H and Yoda K  (1997) Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Biochem Biophys Res Commun 241(3):682-6
3) Jungmann J, et al.  (1999) The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. J Biol Chem 274(10):6579-85