PTK2/YJR059W Summary Help

Standard Name PTK2 1
Systematic Name YJR059W
Alias STK2 2
Feature Type ORF, Verified
Description Putative serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication (1, 3, 4)
Name Description Putative serine/Threonine protein Kinase
Chromosomal Location
ChrX:545787 to 548243 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTK2 GO evidence and references
  View Computational GO annotations for PTK2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 132 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
485 total interaction(s) for 436 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 201
  • PCA: 1
  • Reconstituted Complex: 5

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 3
  • Dosage Rescue: 4
  • Negative Genetic: 196
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 7
  • Positive Genetic: 35
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 818
Molecular Weight (Da) 91,400
Isoelectric Point (pI) 9.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:545787 to 548243 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2457 545787..548243 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003820
References cited on this page View Complete Literature Guide for PTK2
1) Nozaki T, et al.  (1996) A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun 228(2):452-8
2) Kaouass M, et al.  (1997) The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae. Mol Cell Biol 17(6):2994-3004
3) Erez O and Kahana C  (2002) Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun 295(5):1142-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61