ESS1/YJR017C Summary Help

Standard Name ESS1 1
Systematic Name YJR017C
Alias PTF1 2 , PIN1
Feature Type ORF, Verified
Description Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 (3, 4, 5)
Name Description ESSential 6
Chromosomal Location
ChrX:467033 to 466521 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 17 cM
Gene Ontology Annotations All ESS1 GO evidence and references
  View Computational GO annotations for ESS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Classical genetics
Large-scale survey
reduction of function
562 total interaction(s) for 504 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 7
  • Biochemical Activity: 1
  • Far Western: 1
  • PCA: 2
  • Protein-peptide: 66
  • Reconstituted Complex: 4
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 3
  • Dosage Rescue: 21
  • Negative Genetic: 1
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 322
  • Synthetic Lethality: 12
  • Synthetic Rescue: 83

Expression Summary
Length (a.a.) 170
Molecular Weight (Da) 19,405
Isoelectric Point (pI) 9.19
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:467033 to 466521 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 17 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..513 467033..466521 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003778
References cited on this page View Complete Literature Guide for ESS1
1) Hanes SD  (1988) Isolation, Sequence and Mutational Analysis of ESS1, a Gene Essential for Growth in Saccharomyces cerevisiase ()
2) Hani J, et al.  (1995) PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases. FEBS Lett 365(2-3):198-202
3) Hani J, et al.  (1999) Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae. J Biol Chem 274(1):108-16
4) Kops O, et al.  (2002) Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. FEBS Lett 513(2-3):305-11
5) Ma Z, et al.  (2012) Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle. Mol Cell Biol 32(17):3594-607
6) Hanes SD, et al.  (1989) Sequence and mutational analysis of ESS1, a gene essential for growth in Saccharomyces cerevisiae. Yeast 5(1):55-72