Standard Name	SUI2 1
Systematic Name	YJR007W
Feature Type	ORF, Verified
Description	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress (2, 3)
Name Description	SUppressor of Initiator codon 1

Chromosomal Location	ChrX:451020 to 451934 | ORF Map | GBrowse
	Genetic position: 2 cM

	View Computational GO annotations for SUI2
Molecular Function
Manually curated	translation initiation factor activity (TAS)
Biological Process
Manually curated	translational initiation (TAS)
Cellular Component
Manually curated	eukaryotic translation initiation factor 2 complex (IMP, ISS) multi-eIF complex (IDA) ribosome (TAS)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	GCN4 mRNA accumulation: increased heat sensitivity: increased
null	inviable
unspecified	GCN4 mRNA accumulation: increased Gcn4p-lacZ accumulation: decreased Gcn4p-lacZ accumulation: increased His4AUU-lacZ accumulation: increased resistance to 3-aminotriazole: decreased resistance to sirolimus: increased resistance to 1,2,4-triazolealanine and 5-fluorotryptophan: increased resistance to 5-fluorotryptophan: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	164 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 62 Affinity Capture-RNA: 2 Affinity Capture-Western: 23 Co-fractionation: 5 Reconstituted Complex: 10 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 17 Phenotypic Enhancement: 1 Positive Genetic: 27 Synthetic Growth Defect: 7 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:451020 to 451934 | ORF Map | GBrowse
	Genetic position: 2 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..915 451020..451934 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003767