SUI2/YJR007W Summary Help

Standard Name SUI2 1
Systematic Name YJR007W
Feature Type ORF, Verified
Description Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress (2, 3)
Name Description SUppressor of Initiator codon 1
Chromosomal Location
ChrX:451020 to 451934 | ORF Map | GBrowse
Gbrowse
Genetic position: 2 cM
Gene Ontology Annotations All SUI2 GO evidence and references
  View Computational GO annotations for SUI2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
unspecified
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
167 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 64
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 23
  • Co-fractionation: 5
  • Reconstituted Complex: 10
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 17
  • Phenotypic Enhancement: 1
  • Positive Genetic: 27
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 304
Molecular Weight (Da) 34,717
Isoelectric Point (pI) 4.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:451020 to 451934 | ORF Map | GBrowse
SGD ORF map
Genetic position: 2 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..915 451020..451934 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003767
References cited on this page View Complete Literature Guide for SUI2
1) Donahue TF, et al.  (1988) Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process. Cell 54(5):621-32
2) Laurino JP, et al.  (1999) The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif. Mol Cell Biol 19(1):173-81
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76