APL1/YJR005W Summary Help

Standard Name APL1
Systematic Name YJR005W
Alias YAP80
Feature Type ORF, Verified
Description Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex (1, 2, 3, 4)
Name Description clathrin Adaptor Protein complex Large chain
Chromosomal Location
ChrX:445923 to 448025 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APL1 GO evidence and references
  View Computational GO annotations for APL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
87 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • PCA: 3
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 58
  • Positive Genetic: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 700
Molecular Weight (Da) 80,453
Isoelectric Point (pI) 6.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:445923 to 448025 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2103 445923..448025 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003765
References cited on this page View Complete Literature Guide for APL1
1) Rad MR, et al.  (1995) Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci 108 ( Pt 4)():1605-15
2) Kirchhausen T  (1990) Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Mol Cell Biol 10(11):6089-90
3) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
4) Yeung BG, et al.  (1999) Adaptor complex-independent clathrin function in yeast. Mol Biol Cell 10(11):3643-59