OPT1/YJL212C Summary Help

Standard Name OPT1 1
Systematic Name YJL212C
Alias HGT1 2 , GSH11 3
Feature Type ORF, Verified
Description Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family (2, 4, 5)
Name Description OligoPeptide Transporter 1
Chromosomal Location
ChrX:36249 to 33850 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All OPT1 GO evidence and references
  View Computational GO annotations for OPT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 20 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
unspecified
Resources
46 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 15
  • Phenotypic Enhancement: 1
  • Positive Genetic: 14
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 799
Molecular Weight (Da) 91,615
Isoelectric Point (pI) 9.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:36249 to 33850 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2400 36249..33850 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003748
References cited on this page View Complete Literature Guide for OPT1
1) Hauser M, et al.  (2000) Enkephalins are transported by a novel eukaryotic peptide uptake system. J Biol Chem 275(5):3037-41
2) Bourbouloux A, et al.  (2000) Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. J Biol Chem 275(18):13259-65
3) Miyake T, et al.  (2002) A novel cis-acting cysteine-responsive regulatory element of the gene for the high-affinity glutathione transporter of Saccharomyces cerevisiae. Mol Genet Genomics 266(6):1004-11
4) Hauser M, et al.  (2001) Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae. Mol Membr Biol 18(1):105-12
5) Osawa H, et al.  (2006) ScOPT1 and AtOPT4 function as proton-coupled oligopeptide transporters with broad but distinct substrate specificities. Biochem J 393(Pt 1):267-75