PRP21/YJL203W Summary

PRP21 BASIC INFORMATION

Standard Name	PRP21 1
Systematic Name	YJL203W
Alias	SPP91
Feature Type	ORF, Verified
Description	Subunit of the SF3a splicing factor complex, required for spliceosome assembly (2)
Name Description	Pre-mRNA Processing 1

GO Annotations	All PRP21 GO evidence and references
	View Computational GO annotations for PRP21
Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IDA)
Cellular Component
Manually curated	colocalizes_with U2 snRNP (TAS) U2 snRNP (TAS) U2-type prespliceosome (IDA)

Mutant Phenotype	All PRP21 Phenotype details and references
Classical genetics
conditional	unspliced intron-containing RNA accumulation: abnormal heat sensitivity: increased
Large-scale survey
null	inviable

Interactions	PRP21 All interactions details and references
	90 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-MS: 58 Co-purification: 1 Reconstituted Complex: 4 Two-hybrid: 22
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Lethality: 2 Synthetic Rescue: 2

Sequence Information

ChrX:53341 to 54183 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..843	53341..54183	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003739

PRP21 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PRP21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRP21]

1)	Vijayraghavan U, et al. (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
2)	Hodges PE and Beggs JD (1994) RNA splicing. U2 fulfils a commitment. Curr Biol 4(3):264-7

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