PHO90/YJL198W Summary Help

Standard Name PHO90
Systematic Name YJL198W
Feature Type ORF, Verified
Description Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description PHOsphate metabolism
Chromosomal Location
ChrX:60844 to 63489 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PHO90 GO evidence and references
  View Computational GO annotations for PHO90
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
66 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 28
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 11
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 881
Molecular Weight (Da) 97,687
Isoelectric Point (pI) 7.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:60844 to 63489 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2646 60844..63489 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003734
References cited on this page View Complete Literature Guide for PHO90
1) Wykoff DD and O'Shea EK  (2001) Phosphate transport and sensing in Saccharomyces cerevisiae. Genetics 159(4):1491-9
2) Auesukaree C, et al.  (2003) Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Biochem Biophys Res Commun 306(4):843-50
3) Pinson B, et al.  (2004) Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae. J Biol Chem 279(34):35273-80
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61