PFD1/YJL179W Summary Help

Standard Name PFD1 1
Systematic Name YJL179W
Alias GIM6
Feature Type ORF, Verified
Description Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation (1, 2, 3)
Name Description PreFolDin 1
Chromosomal Location
ChrX:88787 to 89116 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PFD1 GO evidence and references
  View Computational GO annotations for PFD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
306 total interaction(s) for 230 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 3
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 99
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 100
  • Synthetic Growth Defect: 13
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 43
  • Synthetic Rescue: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 109
Molecular Weight (Da) 12,782
Isoelectric Point (pI) 9.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:88787 to 89116 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..330 88787..89116 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003715
References cited on this page View Complete Literature Guide for PFD1
1) Vainberg IE, et al.  (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93(5):863-73
2) Siegers K, et al.  (1999) Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. EMBO J 18(1):75-84
3) Millan-Zambrano G, et al.  (2013) The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation. PLoS Genet 9(9):e1003776