YJL171C Summary Help

Reserved Name TOH1 1

This name is reserved with SGD according to the Gene Naming Guidelines agreed upon by the yeast community.
For more information about this reservation, please see the Locus History.

Systematic Name YJL171C
Feature Type ORF, Verified
Description GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress (2, 3, 4, 5, 6, 7)
Name Description TOS One Homolog 1
Chromosomal Location
ChrX:100894 to 99704 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All YJL171C GO evidence and references
  View Computational GO annotations for YJL171C
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Large-scale survey
32 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 18
  • Positive Genetic: 9
  • Synthetic Growth Defect: 2

Expression Summary
Length (a.a.) 396
Molecular Weight (Da) 42,958
Isoelectric Point (pI) 4.67
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:100894 to 99704 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1191 100894..99704 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003707
References cited on this page View Complete Literature Guide for YJL171C
1) Philippsen P  (2013) personal communication
2) Hamada K, et al.  (1999) Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins. J Bacteriol 181(13):3886-9
3) Hamada K, et al.  (1998) Screening for glycosylphosphatidylinositol (GPI)-dependent cell wall proteins in Saccharomyces cerevisiae. Mol Gen Genet 258(1-2):53-9
4) Lagorce A, et al.  (2003) Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 278(22):20345-57
5) Garcia R, et al.  (2004) The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. J Biol Chem 279(15):15183-95
6) Hagen I, et al.  (2004) Sed1p and Srl1p are required to compensate for cell wall instability in Saccharomyces cerevisiae mutants defective in multiple GPI-anchored mannoproteins. Mol Microbiol 52(5):1413-25
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76