Standard Name	SET2 1
Systematic Name	YJL168C
Alias	EZL1
Feature Type	ORF, Verified
Description	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p (2, 3, 4, 5, 6)
Name Description	SET domain-containing 7
Gene Product Alias	KMT3 8

Chromosomal Location	ChrX:104428 to 102227 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SET2
Molecular Function
Manually curated	histone methyltransferase activity (ISS) histone methyltransferase activity (H3-K36 specific) (IDA, IMP)
Biological Process
Manually curated	ascospore formation (IMP) DNA-dependent transcription, elongation (IDA, IPI) histone deacetylation (IMP) histone methylation (IDA, IMP) negative regulation of antisense RNA transcription (IMP) negative regulation of histone H3-K14 acetylation (IMP) negative regulation of histone H3-K9 acetylation (IMP) negative regulation of reciprocal meiotic recombination (IMP) positive regulation of histone acetylation (IGI) regulation of DNA-dependent DNA replication initiation (IMP) regulation of transcription, DNA-dependent (IDA, IMP)
Cellular Component
Manually curated	nucleus (IPI)

Classical genetics
null	X ray resistance: decreased chronological lifespan: decreased meiotic recombination: increased H3 K36 modification: absent histone H3 modification: increased resistance to 6-azauracil: increased resistance to 6-azauracil: decreased silencing: increased
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to acetic acid: increased resistance to mycophenolic acid: increased resistance to sirolimus: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to wortmannin: normal resistance to doxorubicin: decreased resistance to benzo[a]pyrene: decreased sporulation efficiency: increased stress resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	726 total interaction(s) for 390 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 1 Affinity Capture-Western: 17 Biochemical Activity: 2 Co-localization: 2 Protein-peptide: 31 Reconstituted Complex: 10 Two-hybrid: 28
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 289 Phenotypic Enhancement: 9 Phenotypic Suppression: 2 Positive Genetic: 47 Synthetic Growth Defect: 145 Synthetic Lethality: 71 Synthetic Rescue: 22
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:104428 to 102227 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2202 104428..102227 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003704