SUMMARY PARAGRAPH for FAR1
The cyclin dependent kinase inhibitor Far1p is able to inactivate Cdc28p/Clnp complexes, and thus helps stop the cell cycle at START in G1 (2, 6). This is important for mating, in which haploid cells of opposite mating type synchronize their cell cycles by arresting at START, so that they can fuse and become a diploid. Transcription of FAR1 is induced by mating pheromone, in a Ste12p-dependent manner (1). Far1p levels are also controlled by ubiquitin-mediated proteolysis; Far1p is unstable throughout the cell cycle except during G1 (4). Phosphorylation by the MAP kinase homolog Fus3p may help regulate Far1p's association with the Cdc28p/Cln2p complex (7). Far1p may also serve another function in the cell, as part of a Cdc24p-G/beta/gamma-Far1p complex that acts as a landmark for oriented growth during mating (3, 8). This would be made possible by the movement of Far1p from the nucleus to the cytoplasm in response to mating pheromone (8).
Last updated: 1999-09-01