FAR1/YJL157C Summary 
FAR1 BASIC INFORMATION
| Standard Name | FAR1 1 |
|---|---|
| Systematic Name | YJL157C |
| Feature Type | ORF, Verified |
| Description | Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate (1, 2, 3, 4 and see Summary Paragraph) 
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| Name Description | Factor ARrest 1 |
| GO Annotations | All FAR1 GO evidence and references |
|---|---|
| View Computational GO annotations for FAR1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Regulatory Role | |
|---|---|
| Regulatory modules | predicted: stressResponse ( 601 , 493 , 427 ) |
| Mutant Phenotype | All FAR1 Phenotype details and references |
|---|---|
| Classical genetics | |
| null |
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| overexpression |
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| unspecified | |
| Large-scale survey | |
| null | |
| overexpression |
| Interactions | FAR1 All interactions details and references |
|---|---|
| 102 total interaction(s) for 56 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
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| Primary SGDID | S000003693 |
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FAR1 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for FAR1
SUMMARY PARAGRAPH for FAR1
The cyclin dependent kinase inhibitor Far1p is able to inactivate Cdc28p/Clnp complexes, and thus helps stop the cell cycle at START in G1 (2, 5). This is important for mating, in which haploid cells of opposite mating type synchronize their cell cycles by arresting at START, so that they can fuse and become a diploid. Transcription of FAR1 is induced by mating pheromone, in a Ste12p-dependent manner (1). Far1p levels are also controlled by ubiquitin-mediated proteolysis; Far1p is unstable throughout the cell cycle except during G1 (4). Phosphorylation by the MAP kinase homolog Fus3p may help regulate Far1p's association with the Cdc28p/Cln2p complex (6). Far1p may also serve another function in the cell, as part of a Cdc24p-G/beta/gamma-Far1p complex that acts as a landmark for oriented growth during mating (3, 7). This would be made possible by the movement of Far1p from the nucleus to the cytoplasm in response to mating pheromone (7).
Last updated: 1999-09-01
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FAR1]
| 1) | Chang F and Herskowitz I (1990) Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63(5):999-1011 |
| 2) | Peter M and Herskowitz I (1994) Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1. Science 265(5176):1228-31 |
| 3) | Nern A and Arkowitz RA (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202 |
| 4) | Henchoz S, et al. (1997) Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev 11(22):3046-60 |
| 5) | Mendenhall MD (1998) Cyclin-dependent kinase inhibitors of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Curr Top Microbiol Immunol 227():1-24 |
| 6) | Peter M, et al. (1993) FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 73(4):747-60 |
| 7) | Butty AC, et al. (1998) The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science 282(5393):1511-6 |
