Standard Name	SFH5 1
Systematic Name	YJL145W
Feature Type	ORF, Verified
Description	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress (1, 2, 3, 4)
Name Description	Sec Fourteen Homolog 1

Chromosomal Location	ChrX:145160 to 146044 | ORF Map | GBrowse

	View Computational GO annotations for SFH5
Molecular Function
Manually curated	NOT phosphatidylcholine transporter activity (IDA) phosphatidylinositol transporter activity (IDA)
Biological Process
Manually curated	Golgi to plasma membrane protein transport (IGI) phosphatidylinositol metabolic process (IGI) phospholipid transport (IDA) regulation of establishment of cell polarity (IGI) regulation of exocytosis (IGI)
Cellular Component
Manually curated	cell periphery (IDA) cortical endoplasmic reticulum (IDA) cytosol (IDA) plasma membrane (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
overexpression	RFP-Cdc42p distribution: abnormal
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to mefloquine: decreased resistance to BPS: decreased resistance to benzo[a]pyrene: increased sporulation: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	20 total interaction(s) for 17 unique genes/features.
Physical Interactions	Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 7 Phenotypic Suppression: 3 Positive Genetic: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:145160 to 146044 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..885 145160..146044 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003681