Standard Name	YAK1 1
Systematic Name	YJL141C
Feature Type	ORF, Verified
Description	Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose (2, 3, 4, 5, 6, 7)
Name Description	Yet Another Kinase 1

Chromosomal Location	ChrX:150390 to 147967 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YAK1
Molecular Function
Manually curated	protein kinase activity (IDA) protein serine/threonine kinase activity (IDA, IMP) protein tyrosine kinase activity (IDA, IMP)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	protein phosphorylation (IDA, IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (511, 433)

Classical genetics
null	dessication resistance: decreased GFP-HA-Bcy1p distribution: abnormal HA-Bcy1p1-124 modification: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased dessication resistance: decreased haploproficient resistance to dimethyl sulfoxide: decreased resistance to methyl methanesulfonate: decreased stress resistance: increased vegetative growth: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	171 total interaction(s) for 137 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Biochemical Activity: 17 Reconstituted Complex: 20 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 17 Negative Genetic: 51 Phenotypic Enhancement: 2 Positive Genetic: 8 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:150390 to 147967 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2424 150390..147967 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003677