Standard Name	TRK1 1
Systematic Name	YJL129C
Feature Type	ORF, Verified
Description	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	TRansport of potassium (K)

Chromosomal Location	ChrX:177306 to 173599 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TRK1
Molecular Function
Manually curated	potassium ion transmembrane transporter activity (IDA)
Biological Process
Manually curated	cellular potassium ion homeostasis (IDA)
Cellular Component
Manually curated	membrane raft (IDA) plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	acid pH resistance: decreased lithium(1+) accumulation: decreased metal resistance: increased resistance to edelfosine: decreased resistance to hygromycin B: decreased small molecule transport: decreased vegetative growth: decreased vegetative growth: absent
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased metal resistance: decreased resistance to (S)-lactic acid: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to edelfosine: decreased resistance to cisplatin: decreased resistance to glucose: decreased resistance to doxorubicin: decreased resistance to sorbate: decreased resistance to farnesol: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to wortmannin: decreased telomere length: decreased toxin resistance: increased transposable element transposition: decreased utilization of nitrogen source: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	100 total interaction(s) for 54 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 2 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 9 Negative Genetic: 3 Phenotypic Enhancement: 11 Phenotypic Suppression: 6 Synthetic Growth Defect: 26 Synthetic Lethality: 7 Synthetic Rescue: 26
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:177306 to 173599 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3708 177306..173599 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003665