MDV1/YJL112W Summary Help

Standard Name MDV1 1
Systematic Name YJL112W
Alias FIS2 2 , GAG3 , NET2
Feature Type ORF, Verified
Description Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Mitochondrial DiVision 1
Chromosomal Location
ChrX:205305 to 207449 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MDV1 GO evidence and references
  View Computational GO annotations for MDV1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
121 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 17
  • Co-crystal Structure: 2
  • Co-localization: 4
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 50

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 18
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 714
Molecular Weight (Da) 80,031
Isoelectric Point (pI) 5.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:205305 to 207449 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2145 205305..207449 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003648
References cited on this page View Complete Literature Guide for MDV1
1) Tieu Q and Nunnari J  (2000) Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J Cell Biol 151(2):353-66
2) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
3) Fekkes P, et al.  (2000) Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol 151(2):333-40
4) Cerveny KL and Jensen RE  (2003) The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria. Mol Biol Cell 14(10):4126-39
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61