Standard Name	IME2 (see Nomenclature conflict Note)
Systematic Name	YJL106W
Alias	SME1
Feature Type	ORF, Verified
Description	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p (1, 2)
Name Description	Inducer of MEiosis 3

Chromosomal Location	ChrX:221390 to 223327 | ORF Map | GBrowse

	View Computational GO annotations for IME2
Molecular Function
Manually curated	protein kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	protein phosphorylation (IDA) regulation of meiosis (IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
overexpression	mitotic recombination: increased nuclear morphology: abnormal resistance to nocodazole: decreased
reduction of function	meiosis: abnormal
unspecified	meiotic recombination: decreased sporulation: absent
Large-scale survey
null	competitive fitness: decreased sporulation: absent sporulation efficiency: decreased viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	192 total interaction(s) for 171 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 71 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 5 Dosage Lethality: 1 Dosage Rescue: 6 Negative Genetic: 74 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:221390 to 223327 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1938 221390..223327 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003642