KHA1/YJL094C Summary Help

Standard Name KHA1
Systematic Name YJL094C
Feature Type ORF, Verified
Description Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies (1, 2, 3, 4)
Chromosomal Location
ChrX:254442 to 251821 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KHA1 GO evidence and references
  View Computational GO annotations for KHA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
35 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 12
  • Positive Genetic: 2
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 873
Molecular Weight (Da) 97,110
Isoelectric Point (pI) 6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:254442 to 251821 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2622 254442..251821 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003630
References cited on this page View Complete Literature Guide for KHA1
1) Ramirez J, et al.  (1998) A Saccharomyces cerevisiae mutant lacking a K+/H+ exchanger. J Bacteriol 180(22):5860-5
2) Maresova L and Sychrova H  (2005) Physiological characterization of Saccharomyces cerevisiae kha1 deletion mutants. Mol Microbiol 55(2):588-600
3) Flis K, et al.  (2005) The functioning of mammalian ClC-2 chloride channel in Saccharomyces cerevisiae cells requires an increased level of Kha1p. Biochem J 390(Pt 3):655-64
4) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54