SRS2/YJL092W Summary Help

SRS2 BASIC INFORMATION

Standard Name SRS2 1
Systematic Name YJL092W
Alias HPR5 2
Feature Type ORF, Verified
Description DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability (3, 4, 5, 6, 7, 8, 9)
Also known as: RADH 2 , RADH1
Name Description Suppressor of Rad Six 1
GO Annotations All SRS2 GO evidence and references
    View Computational GO annotations for SRS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SRS2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SRS2 All interactions details and references
469 total interaction(s) for 216 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 2
  • PCA: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 93
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 55
  • Phenotypic Suppression: 13
  • Synthetic Growth Defect: 106
  • Synthetic Lethality: 121
  • Synthetic Rescue: 46
Sequence Information
ChrX:257417 to 260941 | ORF Map | GBrowse
Gbrowse
Genetic position: -61 cM
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3525 257417..260941 2009-02-18 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003628

SRS2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SRS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SRS2]

1) Lawrence CW and Christensen RB  (1979) Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants. J Bacteriol 139(3):866-76
2) Rong L, et al.  (1991) The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene. Genetics 127(1):75-85
3) Palladino F and Klein HL  (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37
4) Aboussekhra A, et al.  (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9
5) Rong L and Klein HL  (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9
6) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
7) Pfander B, et al.  (2005) SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436(7049):428-33
8) Papouli E, et al.  (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell 19(1):123-33
9) Dhar A and Lahue RS  (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res 36(10):3366-73