SIP4/YJL089W Summary

SIP4 BASIC INFORMATION

Standard Name	SIP4 1, 2
Systematic Name	YJL089W
Feature Type	ORF, Verified
Description	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus (1, 3, 4)
Name Description	SNF1-Interacting Protein 2

GO Annotations	All SIP4 GO evidence and references
	View Computational GO annotations for SIP4
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IDA, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	invasive growth in response to glucose limitation (IMP) positive regulation of gluconeogenesis (IMP, IPI) regulation of transcription from RNA polymerase II promoter (IMP, IPI)
Cellular Component
Manually curated	nucleus (IDA)

Regulatory Role
Binding motifs	SIP4 Transcription Factor Binding Sites and References
	CGGNYNAATGGRR TCCATTSRTCCGR
Regulatory modules	predicted: stressResponse ( 487 )

Mutant Phenotype	All SIP4 Phenotype details and references
Classical genetics
null	viable
Large-scale survey
null	budding index: decreased resistance to 4-nitroquinoline N-oxide: normal resistance to oligomycin: normal resistance to rhodamine 6-G: normal resistance to chloramphenicol: normal resistance to ketoconazole: normal resistance to cycloheximide: normal viable
overexpression	vegetative growth: decreased

Interactions	SIP4 All interactions details and references
	24 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Biochemical Activity: 6 Reconstituted Complex: 1 Two-hybrid: 10
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 3 Phenotypic Suppression: 1

Sequence Information

ChrX:265920 to 268409 | |

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2490	265920..268409	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003625

SIP4 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SIP4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIP4]

1)	Lesage P, et al. (1996) Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16(5):1921-8
2)	Yang X, et al. (1992) A protein kinase substrate identified by the two-hybrid system. Science 257(5070):680-2
3)	Vincent O and Carlson M (1998) Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J 17(23):7002-8
4)	Roth S, et al. (2004) Transcriptional activators Cat8 and Sip4 discriminate between sequence variants of the carbon source-responsive promoter element in the yeast Saccharomyces cerevisiae. Curr Genet 45(3):121-8

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.