EXO70/YJL085W Summary Help

EXO70 BASIC INFORMATION

Standard Name EXO70
Systematic Name YJL085W
Feature Type ORF, Verified
Description Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding (1, 2, 3)
Name Description EXOcyst
GO Annotations All EXO70 GO evidence and references
    View Computational GO annotations for EXO70
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All EXO70 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
Interactions EXO70 All interactions details and references
70 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-Western: 12
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 13
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 10
  • Synthetic Rescue: 1
Sequence Information
ChrX:272821 to 274692 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1872 272821..274692 2009-02-18 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003621

EXO70 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for EXO70

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EXO70]

1) Robinson NG, et al.  (1999) Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70. Mol Cell Biol 19(5):3580-7
2) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
3) He B, et al.  (2007) Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J 26(18):4053-65