NET1/YJL076W Summary Help

NET1 BASIC INFORMATION

Standard Name NET1
Systematic Name YJL076W
Alias ESC5 , CFI1 , SRM8 1
Feature Type ORF, Verified
Description Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure (2, 3, 4)
Name Description Nucleolar silencing Establishing factor and Telophase regulator 3
GO Annotations All NET1 GO evidence and references
    View Computational GO annotations for NET1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NET1 Phenotype details and references
Large-scale survey
null
Interactions NET1 All interactions details and references
97 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-Western: 24
  • Biochemical Activity: 7
  • Co-localization: 1
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Rescue: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
  • Synthetic Rescue: 11
Sequence Information
ChrX:295239 to 298808 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2009-02-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3570 295239..298808 2009-02-18 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003612

NET1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NET1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SNF12Nomenclature conflictBoth NET1/YJL076W and SNF12/YNR023W have been referred to as NET1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NET1]

1) Koltovaya NA, et al.  (2003) NET1 and HFI1 genes of yeast mediate both chromosome maintenance and mitochondrial rho(-) mutagenesis. Yeast 20(11):955-71
2) Straight AF, et al.  (1999) Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97(2):245-56
3) Shou W, et al.  (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97(2):233-44
4) Shou W, et al.  (2001) Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell 8(1):45-55