Standard Name	LAS21
Systematic Name	YJL062W
Alias	GPI7
Feature Type	ORF, Verified
Description	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity (1, 2)
Name Description	Local Anestheticum Sensitive 2

Chromosomal Location	ChrX:317284 to 319776 | ORF Map | GBrowse

	View Computational GO annotations for LAS21
Molecular Function
Manually curated	mannose-ethanolamine phosphotransferase activity (IMP) transferase activity (IMP)
Biological Process
Manually curated	GPI anchor biosynthetic process (IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA) integral to plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	Ccw14p distribution: abnormal Cwp1p distribution: abnormal Hsp150p distribution: abnormal resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal glycogen accumulation: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploproficient heat sensitivity: increased oxidative stress resistance: decreased protein transport: abnormal resistance to tunicamycin: increased resistance to Calcofluor White: decreased resistance to arsenite(3-): decreased resistance to propolis extract: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to dimethyl sulfoxide: decreased resistance to mefloquine: decreased resistance to fenpropimorph: increased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased sporulation: decreased stress resistance: increased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	362 total interaction(s) for 195 unique genes/features.
Physical Interactions	PCA: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 9 Negative Genetic: 249 Phenotypic Enhancement: 4 Phenotypic Suppression: 31 Positive Genetic: 28 Synthetic Growth Defect: 24 Synthetic Lethality: 8 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:317284 to 319776 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2493 317284..319776 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003598