LAS21/YJL062W Summary Help

Standard Name LAS21 1
Systematic Name YJL062W
Alias GPI7
Feature Type ORF, Verified
Description Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity (1, 2)
Name Description Local Anestheticum Sensitive 1
Chromosomal Location
ChrX:317284 to 319776 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LAS21 GO evidence and references
  View Computational GO annotations for LAS21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
451 total interaction(s) for 232 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • PCA: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 9
  • Negative Genetic: 331
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 31
  • Positive Genetic: 34
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 8
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 830
Molecular Weight (Da) 94,850
Isoelectric Point (pI) 6.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:317284 to 319776 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2493 317284..319776 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003598
References cited on this page View Complete Literature Guide for LAS21
1) Tohe A and Oguchi T  (1998) Isolation and characterization of the yeast las21 mutants, which are sensitive to a local anestheticum, tetracaine. Genes Genet Syst 73(6):365-75
2) Benachour A, et al.  (1999) Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. J Biol Chem 274(21):15251-61