YJL055W Summary Help

Systematic Name YJL055W
Feature Type ORF, Uncharacterized
Description Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA (1, 2, 3)
Chromosomal Location
ChrX:333357 to 334094 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YJL055W GO evidence and references
  View Computational GO annotations for YJL055W
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
8 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Positive Genetic: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 245
Molecular Weight (Da) 26,864
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:333357 to 334094 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..738 333357..334094 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003591
References cited on this page View Complete Literature Guide for YJL055W
1) Stepchenkova EI, et al.  (2005) Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast. BMC Genet 6():31
2) Ko N, et al.  (2008) Control of 5-FOA and 5-FU resistance by Saccharomyces cerevisiae YJL055W. Yeast 25(2):155-60
3) Carlsson M, et al.  (2013) A Novel Yae1p-Dependent Mechanism and Modulation of the Pyrimidine Biosynthetic Pathway can both Confer Resistance to 5-Fluorouracil in Yeast. PLoS One 8(10):e52094