Standard Name	IRC8 1
Systematic Name	YJL051W
Feature Type	ORF, Verified
Description	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc (1, 2, 3, 4, 5)
Name Description	Increased Recombination Centers 1

Chromosomal Location	ChrX:339787 to 342255 | ORF Map | GBrowse

	View Computational GO annotations for IRC8
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitotic recombination (IMP)
Cellular Component
Manually curated	cellular bud (IDA)
High-throughput	integral to membrane (ISM)

Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased haploinsufficient mitotic recombination: increased Rad52-YFP distribution: increased resistance to amitrole: decreased resistance to benzo[a]pyrene: decreased resistance to cadmium dichloride: decreased resistance to 4-aminopyridine: decreased resistance to ethylenediaminetetraacetic acid: decreased resistance to 2,4-dinitrophenol: decreased resistance to hydrogen chloride: increased resistance to (S)-lactic acid: increased resistance to cycloheximide: decreased resistance to valeryl salicylate: decreased resistance to sanguinarine: decreased resistance to 2-phenylethylamine: decreased resistance to hydroxyurea: decreased resistance to benzamidine: decreased respiratory growth: decreased rate stress resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased viable
overexpression	resistance to LY-83583: decreased resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	22 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Biochemical Activity: 9 Reconstituted Complex: 1
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Negative Genetic: 3 Positive Genetic: 3 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:339787 to 342255 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2469 339787..342255 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003587