AIM22/YJL046W Summary Help

Standard Name AIM22 1
Systematic Name YJL046W
Alias LIP3 2 , RRG3 3
Feature Type ORF, Verified
Description Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss (1, 2, 4, 5, 6)
Name Description Altered Inheritance rate of Mitochondria 1
Chromosomal Location
ChrX:352386 to 353615 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AIM22 GO evidence and references
  View Computational GO annotations for AIM22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
136 total interaction(s) for 95 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 120
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 409
Molecular Weight (Da) 47,003
Isoelectric Point (pI) 7.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:352386 to 353615 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-12-01
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1230 352386..353615 2011-02-03 2005-12-01
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003582
References cited on this page View Complete Literature Guide for AIM22
1) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2) Schonauer MS, et al.  (2009) Lipoic Acid synthesis and attachment in yeast mitochondria. J Biol Chem 284(35):23234-42
3) Merz S and Westermann B  (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
4) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
5) Steinmetz LM, et al.  (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
6) Tatusov RL, et al.  (1997) A genomic perspective on protein families. Science 278(5338):631-7