RNR2/YJL026W Summary

RNR2 BASIC INFORMATION

Standard Name	RNR2 1
Systematic Name	YJL026W
Alias	CRT6 2
Feature Type	ORF, Verified
Description	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits (3)
Name Description	RiboNucleotide Reductase 1

GO Annotations	All RNR2 GO evidence and references
	View Computational GO annotations for RNR2
Molecular Function
Manually curated	contributes_to ribonucleoside-diphosphate reductase activity (IDA) ribonucleoside-diphosphate reductase activity (IDA)
Biological Process
Manually curated	deoxyribonucleotide biosynthetic process (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) ribonucleoside-diphosphate reductase complex (IDA)

Pathways	de novo biosynthesis of purine nucleotides de novo biosynthesis of pyrimidine deoxyribonucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All RNR2 Phenotype details and references
Classical genetics
unspecified	inviable
Large-scale survey
null	inviable resistance to sulfanilamide: decreased

Interactions	RNR2 All interactions details and references
	55 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Co-crystal Structure: 2 Co-localization: 3 Co-purification: 2 Reconstituted Complex: 6 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Synthetic Lethality: 1

Sequence Information

ChrX:392398 to 393597 | |

This feature contains embedded feature(s): YJL026C-A

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1200	392398..393597	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003563

RNR2 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RNR2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RNR2]

1)	Elledge SJ and Davis RW (1987) Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol 7(8):2783-93
2)	Zhou Z and Elledge SJ (1992) Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics 131(4):851-66
3)	Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.