RRN7/YJL025W Summary

RRN7 BASIC INFORMATION

Standard Name	RRN7 1
Systematic Name	YJL025W
Feature Type	ORF, Verified
Description	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p (2, 3, 4)
Name Description	Regulation of RNA polymerase I 1

GO Annotations	All RRN7 GO evidence and references
	View Computational GO annotations for RRN7
Molecular Function
Manually curated	promoter binding (NAS) RNA polymerase I transcription factor activity (IDA, IMP)
Biological Process
Manually curated	transcription from RNA polymerase I promoter (IDA, IGI) transcription initiation from RNA polymerase I promoter (NAS) transcription of nuclear rRNA large RNA polymerase I transcript (IGI)
Cellular Component
Manually curated	RNA polymerase I core factor complex (IDA)

Mutant Phenotype	All RRN7 Phenotype details and references
Classical genetics
conditional	rRNA species transcribed by RNA polymerase I accumulation: decreased heat sensitivity: increased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	RRN7 All interactions details and references
	23 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 7 Co-purification: 1 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 12

Sequence Information

ChrX:393961 to 395505 | |

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1545	393961..395505	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003562

RRN7 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RRN7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRN7]

1)	Nogi Y, et al. (1991) An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(16):7026-30
2)	Lin CW, et al. (1996) A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae. Mol Cell Biol 16(11):6436-43
3)	Keys DA, et al. (1994) RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. Genes Dev 8(19):2349-62
4)	Lalo D, et al. (1996) RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I. J Biol Chem 271(35):21062-7

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