APS3/YJL024C Summary Help

Standard Name APS3
Systematic Name YJL024C
Alias YKS7 1
Feature Type ORF, Verified
Description Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description clathrin Associated Protein complex Small subunit
Chromosomal Location
ChrX:396592 to 395931 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All APS3 GO evidence and references
  View Computational GO annotations for APS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
109 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 75
  • Phenotypic Suppression: 1
  • Positive Genetic: 12
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 194
Molecular Weight (Da) 21,938
Isoelectric Point (pI) 4.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:396592 to 395931 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..22 396592..396571 2011-02-03 1996-07-31
Intron 23..99 396570..396494 2011-02-03 1996-07-31
CDS 100..662 396493..395931 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003561
References cited on this page View Complete Literature Guide for APS3
1) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
2) Cowles CR, et al.  (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91(1):109-18
3) Stepp JD, et al.  (1997) The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J Cell Biol 139(7):1761-74
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76